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While each of these three challenges are at different scales and have specific scientific teams collaborating on the data acquisition, data analysis, model formulation, and scientific runs of simulations, they also share several common threads.

First, they are all linked by common sets of cancer types that will appear at all three scales i. This project focuses on the machine learning aspect of the three challenges and, in particular, building a single scalable deep neural network code called CANDLE CAN cer D istributed L earning E nvironment that can be used to address all three challenges.

In the RAS pathway problem, we guide multi-scale molecular dynamics MD runs through a large-scale state-space search, using unsupervised learning to determine the scope and scale of the next series of simulations based on the history of previous simulations.

The scale of the deep learning in this problem comes from the size of the state-space O 10 9 that must be navigated and the number of model parameters to describe each state O 10 In the drug response problem, we use supervised machine learning methods to capture the complex, non-linear relationships between the properties of drugs and the properties of the tumors to predict response to treatment and therefore develop a model that can provide treatment recommendations for a given tumor.

In the treatment strategy problem, we use semi-supervised machine learning to automatically read and encode millions of clinical reports into a form that can be computed upon.

With the appropriate precautions, anal sex is mostly safe. However, there are different potential risks that may not be present in vaginal or oral sex.

For example, the anus cannot naturally lubricate itself to reduce discomfort and friction-related concerns, such as skin injuries.

This article will discuss some of the potential risks of anal sex as well as dispel some myths related to the practice. The anus lacks the cells that create the natural lubricant the vagina has.

It also does not have the saliva of the mouth. Lack of lubrication and thinner tissues increase the risk of friction-related tears in the anus and rectum.

Some of these tears may be very small, but they still expose the skin. Because stool that naturally contains bacteria passes through the rectum and anus when leaving the body, the bacteria can potentially invade the skin through these tears.

This increases the risk of anal abscesses, a deep skin infection that usually requires treatment with antibiotics. Using spermicides can also increase the risk of anal irritation.

People should avoid them during anal sex. Because anal sex can lead to bacterial infections in the ways we mention above, it can also increase the risk of sexually transmitted infections STIs.

For example, because the skin is more likely to tear during anal sex than during vaginal sex, there is greater opportunity to spread STIs. Examples of these include chlamydia , gonorrhea , hepatitis , HIV , and herpes.

These can be long-term conditions, as many STIs do not have a cure. In receptive anal sex, or bottoming, HIV is 13 times more likely to infect the bottom partner than the insertive partner.

They should also pay attention to the type of lubricant they use, as oil-based lubricants such as petroleum jelly can damage latex condoms.

Water-based lubricants are safer to use with condoms. There are several water-based lubricants, such as K-Y jelly and Astroglide , available for purchase online.

A article in the journal Sexually Transmitted Infections suggests that using saliva as a lubricant is a risk factor for gonorrhea in men who have sex with men.

As a result, using a commercial lubricant may be a safer choice. Condoms are not percent effective at preventing STIs. Hemorrhoids are areas of blood vessels inside and outside of the rectum that can cause itching, slight bleeding, and sometimes pain.

Anal sex can irritate existing hemorrhoids for some people. However, anal sex itself is not likely to cause hemorrhoids if a person did not already have them.

It is not always possible to prevent irritating hemorrhoids while having anal sex, but using sufficient lubricant can help minimize the irritation.

This is not entirely true, as it is possible for semen to enter the vagina after anal sex. While this occurrence is not likely, it can happen.

It is important to use a condom when having anal sex to prevent pregnancy. Bleeding after anal sex typically isn't cause for concern.

Though it may be alarming, light spotting immediately after is possible. But if you're…. Rimming, also known as analingus, is the act of orally pleasuring the anus.

This can involve licking, sucking, kissing, and any other pleasurable act…. Oral sex may not pose pregnancy risks, but you can still pass sexually transmitted infections between you and your partner.

If you've never considered…. This is typically a…. Enter: anal douching. Medically reviewed by Janet Brito, Ph. Who can?

Anal vs. What is it? Who can do it? Is an anal orgasm the same thing as a prostate orgasm? What about the A-spot? What does it feel like? Will it hurt at all?

How to get started. Techniques to try.

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The Best ANAL SEX Positions - for SAFE Sex

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